Results from these analyses showed that UHg, RHg, and urine KIM-1, but not SCr, levels were significantly increased in cinnabar-treated rats. A rat antibody array was used to analyze expression of cytokines associated with apoptosis. Apoptotic cells were identified and the apoptotic index was calculated. Levels of urinary mercury (UHg), renal mercury (RHg), serum creatinine (SCr), and urine kidney injury molecule 1 (KIM-1) were assessed, and renal pathology was analyzed. To test this role, rats were dosed orally with cinnabar (1 g/kg/day) for 8 weeks or 12 weeks, and the control rats were treated with 5% carboxymethylcellulose solution. The aim of this study was to explore the role of apoptosis in cinnabar-induced renal injury in rats.
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